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| The Effect Caused by Low Dose Radiation on the Immune Function of Myelomonocytic Leukemia Mice |
| Li Guang-zhou, LI Xian-jun, YU Ming-ming, et al |
| Department of Nuclear Medicine, Weifang Medical College Affiliated Hospital, Weifang 261031 China |
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Abstract Objective To investigate the effects caused by low dose radiation on the level of IL-2, TNFα and SOD in serum of myelomonocytic leukemia mice.Methods 48 experimental animal models of myelomonocytic leukemia were randomly divided into 6 groups.All were irradiated with 0mGy, 10mGy, 30mGy, 50mGy, 75mGy and 120mGy LDR respectively.and were to be killed at 24h in order to extract serum samples.The level of IL-2, TNFα and SOD in all the serum samples was examined.Results The level of IL-2, TNFα and SOD among the mice irradiated with different doses was different.A remarkable difference was caused by 50mGy, 75mGy and 120mGy radiation (P all<0.05).75mGy irradiation was the most efficient dose, which caused significant effect on IL-2 and SOD.Conclusion The most effect of immune in myelomonocytic leukemia mice could be significantly caused by 75mGy radiation.
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Received: 17 September 2006
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