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| Experiment of Radioprotective Early Radiation Damage of Sarcandra Glabra on Salivary Gland: Observe the Tissue Morphology following fractionated Radiation on Head-neck Region in Guinea-pig Models |
| QIN Jian1, TENG Jia-an1, WANG Ren-sheng1, et al |
| Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Nanning 530007 China |
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Abstract Objective To investigate the ability of Sarcandra glabra extracts to ameliorate the early radiation damage on salivary gland in guinea-gig models, to promote the gland recovery as continued administration after radiation, as well as analyzed the possible mechanism.Methods 50 guinea-pigs were randomly divided into normal control group, radiation control group (radio-control) and medicine radiation group (med-group).In the last 2 groups, A、B observation groups were set up at total dose 50Gy and 60 days after 50Gy, respectively.Gamma rays and fractionated radiation delivered to head-neck region were applied, and Sarcandra glabra extracts and 0.9% normal sodium were administered to them respectively.Body weight, parotid gland weight, histopathologic change, remaining gland areas and inflammatory cell counts were observed.Results The body weight of 2 radiation groups grew by different speed after weight loss in the initial stage of radiation.Med-group performed better in body weight, histomorphology and remaining gland areas, when compared to radio-control.Parotid gland atrophy and interstitial fibrosis occurred to some extent after radiation.The gland weight of group B were higher than that groups A and normal-control group, med-group B was the highest one (P<0.05).The postradiation remaining gland areas declined in varying degrees.It enlarged in med-group B than in med-group A (P<0.05) while there was no change between 2 radio-control groups (P>0.05).The inflammatory cell counts of radio-control was higher than that of the other groups (P<0.05).No differences were observed between med-groups and normal control group (P>0.05).Conclusion Sarcandra glabra extracts can protect early damage induced by radiation on parotid gland in guine-pig models, and help gland recover as continued administration after radiation ended.Alleviating the inflammatory reaction induced by radiation may be one of the mechanisms of radioprotection.
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Received: 21 February 2008
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