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| Protective Effect Study of E838 on Hematopoietic Function in Radiation-exposed Mice |
| WANG Yue-ying, LI De-guan, WU Hong-ying, et al |
| Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin Key laboratory of Molecular Nuclear Medicine, Tianjin 300192 China |
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Abstract Objective To study the protective effects of E838 on the hematopoietic function in radiation exposed mice。Methods Colony-forming unit of spleen (CFU-S), the nucleated cells in bone marrow (BMNC)and spleen index were used to investigated the protective effects of E838 on hematopoietic function in mice irradiated with 7.5 Gy.Results On the 9 th day after irradiation, the CFU-S, BMNC numbers and spleen index of mice treated with E838 became obviously higher compared with these in the negative control group (P<0.001).The numbers of BMNC in the three E838 groups were higher than these in nilestrio group (P<0.001), compared with ethinyl estradiol group, the numbers of BMNC in middle and high dose E838 group increased (P<0.05).The spleen index in the three E838 groups were significantly greater than those both in negative control group and in nilestrio group (P<0.001).Conclusion The results showed that E838 could reduced the hematopoietic damage induced by irradiation.
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Received: 30 January 2008
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