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| Research on how the variation of bladder volume impacts upon the dose distribution of rectal cancer undergoing postoperative in intensity modulated radiation therapy |
| XUE Hongyuan, LIN Rong, ZENG Zili, QIN Shufu, LIN Feng, TAN Yong |
| Liuzhou Municipal Liutie Central Hospital, Liuzhou 545007 China |
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Abstract Objective In order to study how the variation of bladder volume impacts on the distribution of the irradiated dose of planning target volume and normal tissue volume in intensity modulated radiation therapy(IMRT), and to provide reference material for rectal cancer undergoing postoperative IMRT.Methods 19 pathologically confirmed idiopathic patients are taken computed tomography (CT) scan under two situations-bladders full and bladders empty. Making use of those CT images, we delineate their planning target volumes and surrounding normal tissues for the two situations in treatment planning system (TPS). The results are compared.Results Contrasting bladder full and empty situations, we find that the dose of PTV and femoral head do not variate obviously (P>0.05). However, the dose statistical results of bladder, bowl and colon are 0.019, 0.022 and 0.037 (P<0.05). These differences are obvious on statistics.Conclusion In rectal cancer undergoing postoperative IMRT, compare to bladder empty situation, the irradiated volume and dose of bladder, bowl and colon reduce obviously when bladder is full. But the impact of PTV and femoral head could be ignored in these cases.
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Received: 14 August 2017
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[1] 侯晓荣.直肠及肛门癌[C]//张福泉.放射治疗科诊断常规[M].北京:人民卫生出版社,2004,81.
[2] 金晶.直肠癌[C]//殷蔚伯,余子豪,徐国镇,等.肿瘤放射治疗学[M].4版.北京:中国协和医科大学出版社,2008,855-878.
[3] Tinger A.Michalski J M,Cheng A,et al.A critical evaluation of the planning target volume for 32 d conformal radiotherapy of prostate cancer[J].Int J Radiat 0ncol Biol Phys,1988,42(1):213-221.
[4] Lebesque JV,Bruce AM,KIoes AP,et al.Variation in volumes,dose-volumes histograms, and estimated normal tissue complication probabilities of rectum and bladder during conformal radiotherapy of T3 prostate cancer[J].Int J Radiat 0ncol Biol Phys,1995,33(5):1109-1119.
[5] HE Yu-xiang,AI Yong,CAI Yong,ZHU Xiang-gao,et al.Analysis of influence factors on the volume of pelvic bowel irradiated for rectal cancer[J].Chin J Radiol Med Prot,2007,27(5):482-485.
[6] 刘跃平,刘新帆,李哗雄,等.前列腺癌三维适形放疗中体位对靶区和正常组织体积及照射剂量的影响[J].中华放射肿瘤学杂志,2005,14(5):422-426.
[7] Chavaudra J.Bridier A.Definition of volumes in external radiotherapy:ICRU reports 50 and 62[J].Cancer Radiother,2001,5:472-478.
[8] Roels S, Duthoy W, Haustermans K,et al.Definition and delincation of the clinical target volume for rectal cancerl[J].Int Radiat Oncol Biol Phys,2006,65:1129-1142.
[9] Zelefsky MJ,Crean D,Mageras Gs,et al.Quantification and pre-dietors of pmstate position variability in 50 patients evaluated with multiple CT scans during conformal radiotherapy[J]. Radiother 0ncol,1999,50(2):225-234.
[10] Buchali A,Koswig S,Dinges S,et al.Impact of the filling status of the bladder and rectum on their integral dose distribution and the movement of the uterus in the treatment planning of gynaecological cancer[J].Radiother 0ncol,1999,52(1):29-34.
[11] Pos FJ,Koedooder K,Hulshof MC,et al.Influence of bladder and rectal volume on spatial variability of a bladder tumor during radical radiotherapy[J].Int J radiat 0ncol Biol Phys,2003,55(3):835-841.
[12] Fokdal L,Honore,Hayer M,et al.Impact of changes in bladder and rectal filling volume on organ motion and dose distribution of the bladder in radiotherapy for urinary bladder cancer[J].Int J radiat Oncol Biol Phys,2004,59(2):436-444.
[13] Nuyttens JJ.Robertson JM,Yah D,et al.The influence of small bowel motion on both a conventional three 2 field and intensity modulated radiation therapy(IMRT)for rectal cancer[J].Cancer Radiother,2004,8(5):1297-304.
[14] Lebesque JV,Bruce AM,KIoes AP,et al.Variation in volumes,dose-volumes histograms, and estimated normal tissue complication probabilities of rectum and bladder during conformal radiotherapy of T3 prostate cancer[J].Int J Radiat 0ncol Biol Phys,1995,33(5):1109-1119. |
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