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| Multicenter Study of Radiotherapy Combined with Sarcandra Glabra for Nasopharyngeal Carcinoma |
| WEI Bo1, WANG Ren-sheng2, FENG Qi-ming1, et al |
| Department of Clinical epidemiology, Guangxi Medical University, Nanning 530021 China |
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Abstract Objective To observe the clinical effect of Sarcandra Glabra.Methods 100 patients with non-metastatic nasopharyngeal carcinoma in stage Ⅲ~IVa and untreated before accepted the treatment plan of Sarcandra Glabra combined with chemoradiation in June 2006 to August 2008.Oral intake Sarcandra 3 days before the radiation therapy, once 10g, three times a day, until the end of treatment.Radiotherapy with conventional radiotherapy protocol, chemotherapy with PF program, 100 cases were chosen who were staging Ⅲ~IVa and received intensity modulated radiotherapy combined with concomitant chemotherapy for the program PF as the control study.Results ① Two groups of primary and cervical lymph node metastases, efficience rate are 100%, the test group primary and cervical lymph nodes CR is 69%, 73%, and the control group is 80%, 81%.There is no significant difference between them.②Two groups of acute radiation reactions, leukopenia, and xerostomia are of no difference.The incidence and severity of oral mucositis and skin reaction in control group were lower than test group.③In test group, the 1 year and 2 years, overall survival, disease-free survival, recurrence rate and distant metastasis rates were:97%, 86%, 92%, 70%, 3%, 11%, 6%, 19%;control group was 100%, 93%, 97%, 81%, 1%, 5%, 2%, 12%.The difference was not statistically significant.④There is no statistically difference between two groups of xerostomia and the rate of radioactive tooth decay.There is statistically difference between two groups of difficulty in opening mouth and skin fibrosis, the control group is lower than the test group.Conclusion Intensity-modulated radiation therapy in normal organ tissue protection still has an absolute advantage.But combined chemoradiation plus sarcandra has a significant remission effect on the xerostomia and radioactive tooth decay caused by the deficiency of saliva secretion and it can improve the quality of patients' lives.It can protect parotid glands as well as intensity-modulated radiation therapy.
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Received: 21 June 2010
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