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| Effects on Translocation and Activation of Cerebellar Protein Kinase C in Rabbit by Microwave Irradiation |
| LIU Yong, HUANG Wei-chu, LIU Da-xing, CHENG Xu-hao |
| Center for Disease Control and Prevention of Jinan Military Region, Jinan 250014 China |
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Abstract Objective To investigate the effects of microwave irradiation on translocation and activation of protein kinase C(PKC) in rabbit cerebellum. Methods Thirty rabbits were divided randomly into control and microwave irradiation group(including 0 hour, 3 hours, 12 hours, 24 hours and 72 hours subgroups after irradiation), rabbits of microwave irradiation group were exposed to 90 mW/cm2 Sfrequency range microwave irradiation for 30 minutes, rectal temperature were detected immediately after irradiation and specific absorption rate(SAR) value were calculated, PKC activity of cerebellar neuron endochylema and cytolemma were detected with improved TaKai method. Results Rectal temperature of rabbits increased 2.41℃ after irradiation, and SAR value was 4.65 Kcal/kg. PKC activity of cerebellar neuron endochylema have no significant change, but PKC activity of cerebellar neuron cytolemma decreased significantly after irradiation. Conclusion After 90 mW/cm2 microwave irradiation for 30 min, heating effect was produced in the rabbit bidy, and the capability of cerebellar PKC translocation and activation decreased significantly.
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Received: 03 March 2011
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