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| Protective Effect of Sipunculus Nudus Polysaccharides on 5.0 Gy 60Co γ Irradiation Mice |
| JIANG Ding-wen, SHEN Xian-rong, HE Ying, LI Ke-xian, CHEN Wei, LIU Yu-ming, QIAN Tian-tian, WANG Qing-rong, HOU Deng-yong |
| Naval Medical Research Institute, Shanghai 200433 China |
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Abstract Objective To evaluate the protective effects of sipunculus nudus polysaccharides (SNPS) on mice with irradiation damage induced by 5.0 Gy 60Co γ-ray. Methods 60 mice were divided into control group,model group, nilestriol group and 100 mg/kg·d, 200 mg/kg·d, and 400 mg/kg·d SNPS groups. SNPS was administrated by intra-gastric infusion every day, and nilestriol was administrated by intra-gastric infusion with 3.3 mg/kg,1.67 mg/kg in the day before and after iradiation, respectively. In the fifteenth day,the mice except control group were irradiated by γ-rays of 60Co (0.80 Gy/h) with the dose of 5.0 Gy. Peripheral blood WBC, the spleen index(SI), thymus index(TI), DNA contain in spleen cells and in bone marrow cells, SOD and MDA in serum were detected. Results Peripheral blood WBC in 100mg/kg·d and 200 mg/kg·d SNPS groups were higher than that of model group at the third day after irradiation (P < 0.05). Peripheral blood WBC in 100mg/kg·d, SI in 200 mg/kg·d and 400 mg/kg·d SNPS groups, DNA contain in spleen cells in 200 mg/kg·d SNPS group, DNA contain in in bone marrow cells in 100 mg/kg·d and 200 mg/kg·d SNPS groups, and SOD in serum in three SNPS groups were much higher than that of model group. MDA in three SNPS groups were much lower than that of model group at the fourteenth and third day after irradiation. Conclusion SNPS has radiation protective effects on γ-rays irradiation mice.
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Received: 01 July 2013
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