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| Labeling of Hypericin With Iodine-131 |
| MENG Bin1, MA Ya1, ZHU Wei1, Yicheng Ni2, ZHANG Jian3, SUN Zi-ping1 |
1. Shandong Academy of Medical Sciences;
2. Katholieke Universiteit Leuven;
3. Jiangsu Academy of Traditional Chinese Medicine |
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Abstract Objective The aim of this study is to establish the method for labeling hypericin with iodine-131. Methods we used Iodogen as the oxidant and the hypericin were labelled with iodine-131 by electrophilic substitution. Results In the neutral reaction conditions, using the proper amount of hypericin and Iodogen, the labeling reaction will complete quickly and efficiently and the labeling rate could be as high as 99%. Conclusion The labeling process was relatively simple and the labeling rate was high and the labeled compound was stable.
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Received: 17 August 2013
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