低氘水对<sup>131</sup>I治疗甲状腺癌致辐射性胃肠炎的疗效评价

doi:10.13491/j.issn.1004-714X.2023.05.012

中国辐射卫生

2023, Vol. 32

Issue (5): 538-541 DOI: 10.13491/j.issn.1004-714X.2023.05.012

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低氘水对¹³¹I治疗甲状腺癌致辐射性胃肠炎的疗效评价

朱静^1,2, 张晓懿^1,2, 沈超¹, 徐志红³, 陈伟³

1. 常熟市第二人民医院核医学科，江苏常熟 215500;
2. 放射医学与辐射防护国家重点实验室(苏州大学)，江苏苏州 215123;
3. 苏州思萃同位素技术研究所有限公司，江苏常熟 215500

Evaluation of the therapeutic effect of deuterium depleted water on gastroenteritis induced by ¹³¹I radiation in thyroid cancer treatment

ZHU Jing^1,2, ZHANG Xiaoyi^1,2, SHEN Chao¹, XU Zhihong³, CHEN Wei³

1. Department of Nuclear Medicine, Changshu No.2 People’s Hospital, Changshu 215500 China;
2. State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123 China;
3. Suzhou Sicui Institute of Isotope Technology Company, Ltd, Changshu 215500 China

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摘要目的探讨口服低氘水对¹³¹I治疗甲状腺癌致辐射性胃肠炎的疗效。方法连续收集2022年5月—2023年2月于常熟市第二人民医院核医学科采用 ¹³¹I治疗的甲状腺乳头状癌(下简称甲状腺癌)患者50例，将其分为对照组和实验组，每组25例。对照组予以口服奥美拉唑肠溶胶囊，同时予口服纯净水660 mL tid，连续5 d；实验组在同对照组用药的基础上予口服低氘水660 mL tid，连续5 d。采用Fisher`s精确检验及Kaplan-Meier分析，观察比较2组患者服¹³¹I后辐射性胃肠炎发生情况，及胃肠道临床症状的缓解情况。结果服¹³¹I后第1天至第5天，实验组患者发生胃肠道炎症例数分别为2（8%），5（20%），2(8%) ，1(4%) ，0(0%)；对照组为2（8%），8(32%) ，4（16%），3（12%），1（4%）。2组间胃肠道炎发生率比较差异具有统计学意义（χ²=4.064，P=0.044）。治疗5 d后，实验组患者总有效率96%，高于对照组的76%，2组间差异有统计学意义（χ²=9.105，P=0.025）。结论口服低氘水对¹³¹I治疗甲状腺癌致辐射性胃肠道炎临床症状的缓解具有一定的疗效。建议临床进一步探讨应用。

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关键词 ：低氘水, 甲状腺癌, 辐射性胃肠炎, 疗效评价, ¹³¹I

收稿日期: 2023-03-22

PACS:

X591

基金资助:放射医学与辐射防护国家重点实验室资助项目（GZK1202109）

作者简介: 朱静(1981-),女,江苏常熟人,副主任医师,从事核医学临床诊疗及相关基础研究。E-mail:5311355@qq.com

引用本文:

朱静, 张晓懿, 沈超, 徐志红, 陈伟. 低氘水对¹³¹I治疗甲状腺癌致辐射性胃肠炎的疗效评价[J]. 中国辐射卫生, 2023, 32(5): 538-541.
ZHU Jing, ZHANG Xiaoyi, SHEN Chao, XU Zhihong, CHEN Wei. Evaluation of the therapeutic effect of deuterium depleted water on gastroenteritis induced by ¹³¹I radiation in thyroid cancer treatment. Chinese Journal of Radiological Health, 2023, 32(5): 538-541.

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http://www.zgfsws.com/CN/10.13491/j.issn.1004-714X.2023.05.012 或 http://www.zgfsws.com/CN/Y2023/V32/I5/538

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