Progress on the mechanism of radiation-induced skin injury
WANG Ping, FAN Li, TIAN Mei
Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088 China
王萍, 范莉, 田梅. 放射性皮肤损伤机制的研究进展[J]. 中国辐射卫生, 2022, 31(4): 524-529.
WANG Ping, FAN Li, TIAN Mei. Progress on the mechanism of radiation-induced skin injury. Chinese Journal of Radiological Health, 2022, 31(4): 524-529.
[1] 霍梦慧, 苏锴骏, 焦玲, 等. 放射工作人员职业健康管理调查分析[J]. 中国辐射卫生,2019,28(5):582-585. DOI: 10.13491/j.issn.1004-714X.2019.05.029 Huo MH, Su KJ, Jiao L, et al. Investigation and analysis of occupational health management of radiological workers[J]. Chin J Radiol Health, 2019, 28(5): 582-585. DOI: 10.13491/j.issn.1004-714X.2019.05.029 [2] Singh M, Alavi A, Wong R, et al. Radiodermatitis: a review of our current understanding[J]. Am J Clin Dermatol, 2016, 17(3): 277-292. DOI: 10.1007/s40257-016-0186-4 [3] Hopewell JW. The skin: its structure and response to ionizing radiation[J]. Int J Radiat Biol, 1990, 57(4): 751-773. DOI: 10.1080/09553009014550911 [4] Wan YM, Tu WL, Tang YT, et al. Prevention and treatment for radiation-induced skin injury during radiotherapy[J]. Radiat Med Prot, 2020, 1(2): 60-68. DOI: 10.1016/j.radmp.2020.02.004 [5] Leventhal J, Young MR. Radiation dermatitis: recognition, prevention, and management[J]. Oncology (Williston Park), 2017, 31(12): 885-887,894-899 [6] 杨文峰, 杨志祥, 金增强. 放射性皮肤损伤临床诊断与治疗[J]. 中国辐射卫生,2020,29(1):1-6. DOI: 10.13491/j.issn.1004-714X.2020.01.001 Yang WF, Yang ZX, Jin ZQ. Interpretation of diagnosis of occupational radiation skin diseases[J]. Chin J Radiol Health, 2020, 29(1): 1-6. DOI: 10.13491/j.issn.1004-714X.2020.01.001 [7] Bray FN, Simmons BJ, Wolfson AH, et al. Acute and chronic cutaneous reactions to ionizing radiation therapy[J]. Dermatol Ther (Heidelb), 2016, 6(2): 185-206. DOI: 10.1007/s13555-016-0120-y [8] Ryan JL. Ionizing radiation: the good, the bad, and the ugly[J]. J Invest Dermatol, 2012, 132(3 Pt 2): 985-993. DOI: 10.1038/jid.2011.411. [9] 陈季玲, 李利平. 放射性皮肤损伤的机制与防治进展[J]. 社区医学杂志,2012,10(9):13-16 Chen JL, Li LP. Progress in the mechanism and prevention of radiation-induced skin injury[J]. J Community Med, 2012, 10(9): 13-16 [10] Yoshida T, Goto S, Kawakatsu M, et al. Mitochondrial dysfunction, a probable cause of persistent oxidative stress after exposure to ionizing radiation[J]. Free Radic Res, 2012, 46(2): 147-153. DOI: 10.3109/10715762.2011.645207 [11] Riley PA. Free radicals in biology: oxidative stress and the effects of ionizing radiation[J]. Int J Radiat Biol, 1994, 65(1): 27-33. DOI: 10.1080/09553009414550041 [12] Gutowski M, Kowalczyk S. A study of free radical chemistry: their role and pathophysiological significance[J]. Acta Biochim Pol, 2013, 60(1): 1-16. DOI: 10.18388/abp.2013_1944 [13] 王咏梅. 自由基与谷胱甘肽过氧化物酶[J]. 解放军药学学报,2005,21(5):369-371. DOI: 10.3969/j.issn.1008-9926.2005.05.017 Wang YM. Free radicals and glutathione peroxidase[J]. Pharm J Chin People’s Lib Army, 2005, 21(5): 369-371. DOI: 10.3969/j.issn.1008-9926.2005.05.017 [14] Koerdt S, Tanner N, Rommel N, et al. An immunohistochemical study on the role of oxidative and nitrosative stress in irradiated skin[J]. Cells Tissues Organs, 2017, 203(1): 12-19. DOI: 10.1159/000447584 [15] Xue J, Yu CX, Sheng WJ, et al. The Nrf2/GCH1/BH4 axis ameliorates radiation-induced skin injury by modulating the ROS cascade[J]. J Invest Dermatol, 2017, 137(10): 2059-2068. DOI: 10.1016/j.jid.2017.05.019 [16] Kim JH, Jenrow KA, Brown SL. Mechanisms of radiation-induced normal tissue toxicity and implications for future clinical trials[J]. Radiat Oncol J, 2014, 32(3): 103-115. DOI: 10.3857/roj.2014.32.3.103 [17] 欧丹, 王孝深, 胡超苏. 放射性皮炎预防与治疗研究进展[J]. 中华放射肿瘤学杂志,2019,28(2):151-154. DOI: 10.3760/cma.j.issn.1004-4221.2019.02.014 Ou D, Wang XS, Hu CS. Research advances in the prevention and treatment of radiation-induced dermatitis[J]. Chin J Radiat Oncol, 2019, 28(2): 151-154. DOI: 10.3760/cma.j.issn.1004-4221.2019.02.014 [18] Müller K, Meineke V. Radiation-induced alterations in cytokine production by skin cells[J]. Exp Hematol, 2007, 35(4 Suppl 1): 96-104. DOI: 10.1016/j.exphem.2007.01.017. [19] Janko M, Ontiveros F, Fitzgerald TJ, et al. IL-1 generated subsequent to radiation-induced tissue injury contributes to the pathogenesis of radiodermatitis[J]. Radiat Res, 2012, 178(3): 166-172. DOI: 10.1667/rr3097.1 [20] Kim JW, Lee DW, Choi WH, et al. Development of a porcine skin injury model and characterization of the dose-dependent response to high-dose radiation[J]. J Radiat Res, 2013, 54(5): 823-831. DOI: 10.1093/jrr/rrt016 [21] Jacobson LK, Johnson MB, Dedhia RD, et al. Impaired wound healing after radiation therapy: a systematic review of pathogenesis and treatment[J]. JPRAS Open, 2017, 13: 92-105. DOI: 10.1016/j.jpra.2017.04.001 [22] 王国栋, 王佳琪, 赵云富, 等. PDGF-BB、TNF-α参与电离辐射致小鼠皮肤创面愈合延迟[J]. 第二军医大学学报,2013,34(9):954-959 Wang GD, Wang JQ, Zhao YF, et al. PDGF-BB and TNF-α are involved in delayed skin wound healing in mice exposed to ionizing radiation[J]. Acad J Second Mil Med Univ, 2013, 34(9): 954-959 [23] Borrelli MR, Shen AH, Lee GK, et al. Radiation-induced skin fibrosis: pathogenesis, current treatment options, and emerging therapeutics[J]. Ann Plast Surg, 2019, 83(4S Suppl 1): S59-S64. DOI: 10.1097/SAP.0000000000002098. [24] 付洪海, 周咏, 张志愿, 等. TGF-β1过表达介导的放疗诱导成纤维细胞向肌成纤维细胞分化的体外研究[J]. 中国口腔颌面外科杂志,2012,10(4):266-270 Fu HH, Zhou Y, Zhang ZY, et al. Effect of irradiation induced TGF-β1 overexpression on myofibroblast differentiation of fibroblast[J]. China J Oral Maxillofac Surg, 2012, 10(4): 266-270 [25] Gallet P, Phulpin B, Merlin JL, et al. Long-term alterations of cytokines and growth factors expression in irradiated tissues and relation with histological severity scoring[J]. PLoS One, 2011, 6(12): e29399. DOI: 10.1371/journal.pone.0029399 [26] Yang XJ, Ren HR, Guo XM, et al. Radiation-induced skin injury: pathogenesis, treatment, and management[J]. Aging, 2020, 12(22): 23379-23393. DOI: 10.18632/aging.103932 [27] Gordon KJ, Blobe GC. Role of transforming growth factor-β superfamily signaling pathways in human disease[J]. Biochim Biophys Acta Mol Basis Dis, 2008, 1782(4): 197-228. DOI: 10.1016/j.bbadis.2008.01.006 [28] Wei JL, Wang HR, Wang HH, et al. The role of NLRP3 inflammasome activation in radiation damage[J]. Biomed Pharmacother, 2019, 118: 109217. DOI: 10.1016/j.biopha.2019.109217 [29] Wu TC, Gao JH, Liu W, et al. NLRP3 protects mice from radiation-induced colon and skin damage via attenuating cGAS-STING signaling[J]. Toxicol Appl Pharmacol, 2021, 418: 115495. DOI: 10.1016/j.taap.2021.115495 [30] Fallah M, Shen Y, Brodén J, et al. Plasminogen activation is required for the development of radiation-induced dermatitis[J]. Cell Death Dis, 2018, 9(11): 1051. DOI: 10.1038/s41419-018-1106-8 [31] Kim JH, Kolozsvary AJJ, Jenrow KA, et al. Mechanisms of radiation-induced skin injury and implications for future clinical trials[J]. Int J Radiat Biol, 2013, 89(5): 311-318. DOI: 10.3109/09553002.2013.765055 [32] Park S, Jang H, Kim BS, et al. Directional migration of mesenchymal stem cells under an SDF-1α gradient on a microfluidic device[J]. PLoS One, 2017, 12(9): e0184595. DOI: 10.1371/journal.pone.0184595 [33] Cao JM, Zhu W, Yu DJ, et al. The involvement of SDF-1α/CXCR4 axis in radiation-induced acute injury and fibrosis of skin[J]. Radiat Res, 2019, 192(4): 410-421. DOI: 10.1667/RR15384.1 [34] Okano J, Nakae Y, Nakagawa T, et al. A novel role for bone marrow-derived cells to recover damaged keratinocytes from radiation-induced injury[J]. Sci Rep, 2021, 11(1): 5653. DOI: 10.1038/s41598-021-84818-1 [35] 邱俊. 血管内皮细胞在正常组织放射性损伤中的作用[J]. 肿瘤防治研究,2011,38(10):1211-1213. DOI: 10.3971/j.issn.1000-8578.2011.10.031 Qiu J. The role of vascular endothelial cells in normal tissue radiation injury[J]. Cancer Res Prev Treat, 2011, 38(10): 1211-1213. DOI: 10.3971/j.issn.1000-8578.2011.10.031 [36] Lee CH, Choi EY. Macrophages and inflammation[J]. J Rheum Dis, 2018, 25(1): 11-18. DOI: 10.4078/jrd.2018.25.1.11 [37] 贾瑞, 惠毅, 闫曙光, 等. 巨噬细胞M1/M2型极化与免疫炎症性疾病关系的研究进展[J]. 中国免疫学杂志,2021,37(22):2791-2797. DOI: 10.3969/j.issn.1000-484X.2021.22.019 Jia R, Hui Y, Yan SG, et al. Research progress on relationship between macrophage M1/M2 polarization and immune inflammatory diseases[J]. Chin J Immunol, 2021, 37(22): 2791-2797. DOI: 10.3969/j.issn.1000-484X.2021.22.019 [38] Oishi Y, Manabe I. Macrophages in inflammation, repair and regeneration[J]. Int Immunol, 2018, 30(11): 511-528. DOI: 10.1093/intimm/dxy054 [39] Jung K, Sabri S, Hanson J, et al. Elevated ARG1 expression in primary monocytes-derived macrophages as a predictor of radiation-induced acute skin toxicities in early breast cancer patients[J]. Cancer Biol Ther, 2015, 16(9): 1281-1288. DOI: 10.1080/15384047.2015.1056945