Eclipse计划系统NTO对直肠癌调强放疗计划的影响

doi:10.13491/j.issn.1004-714X.2022.04.017

中国辐射卫生

2022, Vol. 31

Issue (4): 471-476 DOI: 10.13491/j.issn.1004-714X.2022.04.017

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Eclipse计划系统NTO对直肠癌调强放疗计划的影响

吴哲, 刘可, 明智, 王东, 曹俊逸

自贡市第一人民医院肿瘤科，四川自贡 643000

Influence of normal tissue objective on intensity modulated radiation therapy for rectal cancer based on the Eclipse treatment planning system

WU Zhe, LIU Ke, MING Zhi, WANG Dong, CAO Junyi

Department of Oncology, Zigong First People's Hospital, Zigong 643000 China

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摘要目的探讨Eclipse上的优化工具NTO（normal tissue objective）对直肠癌术后调强放疗的剂量影响。方法随机选取20例直肠癌术后患者，每位患者均制定3组调强计划。对照组为手动NTO，其他2组分别为自动NTO和无NTO，在相同的优化条件下，自动NTO和无NTO与对照组比较靶区和危及器官剂量学参数以及机器跳数。结果与对照组相比，自动NTO计划组适形度指数（CI）更差（t = 3.248，P < 0.05），正常组织D_mean高0.6%（t = ?3.678，P < 0.05），危及器官受量和机器跳数差异均无统计学意义（P > 0.05）；无NTO计划组CI较差（t = 16.716，P < 0.05），均匀性指数较好（t = 6.594，P < 0.05），正常组织D_mean高3.19%（t = ?8.560，P < 0.05），除小肠D_max更高外其他危及器官受量差异均无统计学意义（P > 0.05），机器跳数增加3.95%。结论从靶区和危及器官的剂量学结果看，手动NTO和自动NTO、无NTO均能满足临床需求，但无NTO会增加靶区外热点、机器跳数和正常组织D_mean，手动NTO优势不明显，建议自动NTO用于直肠癌固定野调强放疗。

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	吴哲
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关键词 ：直肠癌, 固定野调强, NTO, 剂量学, Eclipse

收稿日期: 2022-01-17

PACS:

R816

作者简介: 吴哲（1991—），男，湖北咸宁人，硕士，放疗物理师，从事放射物理工作。E-mail：wuzhecqu@163.com;

引用本文:

吴哲, 刘可, 明智, 王东, 曹俊逸. Eclipse计划系统NTO对直肠癌调强放疗计划的影响[J]. 中国辐射卫生, 2022, 31(4): 471-476.
WU Zhe, LIU Ke, MING Zhi, WANG Dong, CAO Junyi. Influence of normal tissue objective on intensity modulated radiation therapy for rectal cancer based on the Eclipse treatment planning system. Chinese Journal of Radiological Health, 2022, 31(4): 471-476.

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http://www.zgfsws.com/CN/10.13491/j.issn.1004-714X.2022.04.017 或 http://www.zgfsws.com/CN/Y2022/V31/I4/471

[1] 薛宏元, 林蓉, 曾自力, 等. 膀胱体积的变化对直肠癌术后调强放疗剂量学影响的研究[J]. 中国辐射卫生,2017,26(6):726-729. DOI: 10.13491/j.cnki.issn.1004-714X.2017.06.032
Xue HY, Lin R, Zeng ZL, et al. Research on how the variation of bladder volume impacts upon the dose distribution of rectal cancer undergoing postoperative in intensity modulated radiation therapy[J]. Chin J Radiol Health, 2017, 26(6): 726-729. DOI: 10.13491/j.cnki.issn.1004-714X.2017.06.032
[2] Shi JG, Yang FJ, Ju XB, et al. Comparative study on dosimetry of VMAT and IMRT in assisted radiotherapy after radical resection of rectal cancer[J]. Oncol Lett, 2017, 13(5): 2971-2974. DOI: 10.3892/ol.2017.5842
[3] Yadav P, Yan Y, Paliwal BR. Radiotherapy treatment planning for prostate and nodes using variable planning ring[J]. J Radiother Pract, 2020, 19(4): 399-402. DOI: 10.1017/S146039691900089X
[4] 杨惠惠, 刘金刚, 王兴, 等. 等效均匀剂量优化方法在直肠癌逆向调强放疗中的应用研究[J]. 中国辐射卫生,2020,29(6):682-685,690. DOI: 10.13491/j.issn.1004-714X.2020.06.027
Yang HH, Liu JG, Wang X, et al. Application of equivalent uniform dose optimization in the treatment of rectal cancer with intensity-modulated radiotherapy[J]. Chin J Radiol Health, 2020, 29(6): 682-685,690. DOI: 10.13491/j.issn.1004-714X.2020.06.027
[5] Varian Medical Systems, Inc. Eclipse photon and electron algorithms reference guide[M]. Palo Alto: Varian Medical Systems, 2017.
[6] Nuyttens JJ, Robertson JM, Yan D, et al. The influence of small bowel motion on both a conventional three-field and intensity modulated radiation therapy (IMRT) for rectal cancer[J]. Cancer Radiother, 2004, 8(5): 297-304. DOI: 10.1016/j.canrad.2004.08.001
[7] Hodapp N. Der ICRU-report 83: verordnung, dokumentation und kommunikation der fluenzmodulierten photonenstrahlentherapie (IMRT)[J]. Strahlenther Onkol, 2012, 188(1): 97-100. DOI: 10.1007/s00066-011-0015-x
[8] 吴哲, 庞亚, 王东, 等. 通量平滑度在直肠癌固定野调强放射治疗的剂量学评估[J]. 中国医学装备,2021,18(7):22-27. DOI: 10.3969/J.ISSN.1672-8270.2021.07.006
Wu Z, Pang Y, Wang D, et al. Dosimetric assessment of fluence-smoothness on IMRT of fixed-field on rectal cancer[J]. China Med Equip, 2021, 18(7): 22-27. DOI: 10.3969/J.ISSN.1672-8270.2021.07.006
[9] Wang D, Denittis A, Hu YB. Strategies to optimize stereotactic radiosurgery plans for brain tumors with volumetric-modulated arc therapy[J]. J Appl Clin Med Phys, 2020, 21(3): 45-51. DOI: 10.1002/acm2.12818
[10] Bell JP, Patel P, Higgins K, et al. Fine-tuning the normal tissue objective in eclipse for lung stereotactic body radiation therapy[J]. Med Dosim, 2018, 43(4): 344-350. DOI: 10.1016/j.meddos.2017.11.004
[11] 陈颖, 钟志鹏, 焦杨, 等. 限量环个数对宫颈癌固定野调强放疗计划的影响研究[J]. 医疗卫生装备,2019,40(11):33-37. DOI: 10.19745/j.1003-8868.2019268
Chen Y, Zhong ZP, Jiao Y, et al. Study of influence of number of dose-limiting rings on fixed-fields IMRT plan for cervical cancer[J]. Chin Med Equip J, 2019, 40(11): 33-37. DOI: 10.19745/j.1003-8868.2019268
[12] Wong C, Diamond KR. Optimization of eclipse rapidarc's normal tissue objective to determine a standard setting for use in post-prostatectomy radiotherapy treatment planning[J]. J Med Imaging Radiat Sci, 2013, 44(3): 158. DOI: 10.1016/j.jmir.2013.06.007
[13] Caldeira A, Trinca WC, Flores TP, et al. The influence of normal tissue objective in the treatment of prostate cancer[J]. J Med Imaging Radiat Sci, 2020, 51(2): 312-316. DOI: 10.1016/j.jmir.2020.02.006
[14] 叶芝甫. Eclipse NTO参数的调整对鼻咽癌放疗计划剂量学的影响[J]. 健康前沿,2019,28(3):283-284. DOI: 10.3969/j.issn.9128-6509.2019.03.261
Ye ZF. Effect of adjustment of Eclipse NTO parameters on dosimetry of radiotherapy plan for nasopharyngeal carcinoma[J]. Frontier Health, 2019, 28(3): 283-284. DOI: 10.3969/j.issn.9128-6509.2019.03.261
[15] Gerdán M, Pócza T, Polgár C, et al. The effects of normal tissue objective parameters on lung stereotactic body radiotherapy dose distributions[J]. Magy Onkol, 2021, 65(1): 14-22