胸段食管癌累及野放疗与扩大野放疗对危及器官的辐射剂量学分析

doi:10.13491/j.issn.1004-714X.2022.02.014

中国辐射卫生

2022, Vol. 31

Issue (2): 210-213,218 DOI: 10.13491/j.issn.1004-714X.2022.02.014

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胸段食管癌累及野放疗与扩大野放疗对危及器官的辐射剂量学分析

袁成¹, 刘明锐², 施林心¹, 邵卫仙¹, 王强¹, 杜傲男¹, 张文¹, 孙建伟¹, 苗慧¹

1. 徐州市肿瘤医院，江苏徐州 221005;
2. 南通大学医学院，江苏南通 226001

Dosimetry of organs at risk between involved field radiation and extended field radiation in patients with thoracic esophageal cancer

YUAN Cheng¹, LIU Mingrui², SHI Linxin¹, SHAO Weixian¹, WANG Qiang¹, DU Aonan¹, ZHANG Wen¹, SUN Jianwei¹, MIAO Hui¹

1. Xuzhou Cancer Hospital, Xuzhou 221005 China;
2. Medical College of Nantong University, Nantong 226001 China

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相关文章 (11)

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摘要目的研究胸段食管癌逆向调强放射治疗（IMRT）中累及野照射与扩大野照射对危及器官（OAR）受照剂量的影响。方法 40例胸段食管癌患者分别行累及野靶区勾画和扩大野靶区勾画并勾画危及器官，制定IMRT计划，评估2个计划的靶区适形指数（CI）和均匀性指数（HI）及危及器官的剂量学参数，剂量学参数比较采用配对t检验。结果 2种计划的PTV均能满足处方剂量要求，PTV在CI、HI上相近（P = 0.317、0.130）。两组间平均肺剂量、两肺V₅、两肺V₂₀、两肺V₃₀、脊髓D_mean、心脏D_mean、心脏D_max、心脏V₃₀、心脏V₄₀、心脏V₆₀差异均存在统计学意义（P < 0.01）。结论胸段食管癌患者行累及野照射与扩大野比较，可降低正常器官的受照剂量，从而降低放射性损伤风险。

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	袁成
	刘明锐
	施林心
	邵卫仙
	王强
	杜傲男
	张文
	孙建伟
	苗慧

关键词 ：胸段食管癌, 调强放射治疗, 累及野, 扩大野, 危及器官

收稿日期: 2021-08-07

R144.1

基金资助:徐州市科技局社会发展后补助项目（KC16SH035）；徐州市科技局课题（KC19186）；徐州市科技计划项目（KC19183）

通讯作者: 苗慧，E-mail：13615105270@163.com E-mail: 13615105270@163.com

作者简介: 袁成（1985—），男，江苏徐州人，主治医师，主要从事肿瘤放射治疗工作。E-mail：yuancheng0516@163.com

引用本文:

袁成, 刘明锐, 施林心, 邵卫仙, 王强, 杜傲男, 张文, 孙建伟, 苗慧. 胸段食管癌累及野放疗与扩大野放疗对危及器官的辐射剂量学分析[J]. 中国辐射卫生, 2022, 31(2): 210-213,218.
YUAN Cheng, LIU Mingrui, SHI Linxin, SHAO Weixian, WANG Qiang, DU Aonan, ZHANG Wen, SUN Jianwei, MIAO Hui. Dosimetry of organs at risk between involved field radiation and extended field radiation in patients with thoracic esophageal cancer. , 2022, 31(2): 210-213,218.

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http://www.zgfsws.com/CN/10.13491/j.issn.1004-714X.2022.02.014 或 http://www.zgfsws.com/CN/Y2022/V31/I2/210

[1] Chen W, Zheng R, Baade PD, et al. Cancer Statistics in China, 2015[J]. CA Cancer J Clin, 2016, 66(2): 115-132. DOI: 10.3322/caac.21338
[2] 白文文, 周志国, 张若辉, 等. 食管癌扩大野与累及野3DRT的Meta分析[J]. 中华放射肿瘤学杂志,2016,25(9):923-928. DOI: 10.3760/cma.j.issn.1004-4221.2016.09.003
Bai WW, Zhou ZG, Zhang RH, et al. Therapeutic effects of extended-field and involved-field irradiation in three-dimensional radiotherapy in patients with esophageal cancer: a meta-analysis[J]. Chin J Radiat Oncol, 2016, 25(9): 923-928. DOI: 10.3760/cma.j.issn.1004-4221.2016.09.003
[3] 李晔雄. 肿瘤放射治疗学[M]. 5版. 北京: 中国协和医科大学出版社, 2018: 817-818.
Li YX. Radiation oncology[M]. 5th ed. Beijing: Peking Union Medical College Press, 2018: 817-818.
[4] Lomax Nicoletta J, Scheib Stefan G. Quantifying the degree of conformity in radiosurgery treatment planning[J]. Int J Radiat Oncol Biol Phys, 2003, 55(5): 1409-1419. DOI: 10.1016/S0360-3016(02)04599-6
[5] Kataria Tejinder, Sharma Kuldeep, Subramani Vikraman, et al. Homogeneity Index: An objective tool for assessment of conformal radiation treatments[J]. J Med Phys, 2012, 37(4): 207-213. DOI: 10.4103/0971-6203.103606
[6] 殷蔚伯, 张力军, 杨宗贻, 等. 放射治疗食管癌 3798例临床分析[J]. 中华肿瘤杂志.,1980,3:216-220
Yin WB, Zhang LJ, Yang ZY, et al. An analysis of 3798 cases of esophageal cancer treated by radiation[J]. Chin J Oncol, 1980, 3: 216-220
[7] 杨民生, 五兆星, 王经建, 等. 1160例食管癌放射治疗10年疗效[J]. 中华放射肿瘤学杂志,1992,1(3):174-176
Yang MS, Wu ZX, Wang JJ, et al. Ten year survival of 1160 esophageal cancer patients treated by radiotherapy[J]. Chin J Radiat Oncol, 1992, 1(3): 174-176
[8] Tachibana M, Kinugasa S, Yoshimura H, et al. Clinical outcomes of extended esophagectomy with three-field lymph node dissection for esophageal squamous cell carcinoma[J]. Am J Surg, 2005, 189(1): 98-109. DOI: 10.1016/j.amjsurg.2004.10.001
[9] Zhang XL, Li MH, Meng X, et al. Involved-field irradiation in definitive chemoradiotherapy for locally advanced esophageal squamous cell carcinoma[J]. Radiat Oncol, 2014, 9(1): 64. DOI: 10.1186/1748-717X-9-64
[10] 祝淑钗, 董辉, 刘志坤, 等. 早期食管癌根治性放射治疗不同照射范围的比较研究[J]. 中华放射肿瘤学杂志,2015,24(6):615-618. DOI: 10.3760/cma.j.issn.1004-4221.2015.06.003
Zhu SC, Dong H, Liu ZK, et al. A comparative study of different irradiation ranges in radical radiotherapy for early-stage esophageal cancer[J]. Chin J Radiat Oncol, 2015, 24(6): 615-618. DOI: 10.3760/cma.j.issn.1004-4221.2015.06.003
[11] Lyman JT. Complication probability as assessed from dose volume histograms[J]. Radiat Res Suppl, 1985, 8: S13-S19. DOI: 10.2307/3583506
[12] Mary V Graham, James A Purdy, Bahman Emami, et al. Clinical dose–volume histogram analysis for pneumonitis after 3D treatment for non-small cell lung cancer (NSCLC)[J]. Int J Radiat Oncol Biol Phys, 1999, 45(2): 323-329. DOI: 10.1016/S0360-3016(99)00183-2
[13] Zhao LJ, Wang LH, Ji W, et al. Elevation of plasma TGF-beta1 during radiation therapy predicts radiation-induced lung toxicity in patients with non-small-cell lung cancer: a combined analysis from Beijing and Michigan[J]. Int J Radiat Oncol Biol Phys, 2009, 74(5): 1385-1390. DOI: 10.1016/j.ijrobp.2008.10.065
[14] Pinnix CC, Smith GL, Milgrom S, et al. Predictors of radiation pneumonitis in patients receiving intensity modulated radiation therapy for Hodgkin and non-Hodgkin lymphoma[J]. Int J Radiat Oncol Biol Phys, 2015, 92(1): 175-182. DOI: 10.1016/j.ijrobp.2015.02.010
[15] Satoshi Tanabe, Miyako Myojin, Shinichi Shimizu, et al. Dose-volume analysis for respiratory toxicity in intrathoracic esophageal cancer patients treated with definitive chemoradiotherapy using extended fields[J]. J Radiat Res, 2013, 54(6): 1085-1094. DOI: 10.1093/jrr/rrt047
[16] Albert J. van der Kogel, John P. Kirkpatrick. Radiation dose-volume effects in the spinal cord[J]. Int J Radiat Oncol Biol Phys, 2010, 76(3): S42-S49. DOI: 10.1016/j.ijrobp.2009.04.095
[17] 何宏涛, 王军, 刘青, 等. 急性放射性心脏损伤剂量体积因素分析[J]. 中华肿瘤防治杂志,2014,21(10):767-770
He HT, Wang J, Liu Q, et al. Dose and volume factors to the acute radiation-induced heart disease[J]. Chin J Cancer Prev Treat, 2014, 21(10): 767-770