腰椎转移瘤不同射野角度调强放疗计划的剂量学研究

doi:10.13491/j.issn.1004-714X.2021.02.022

中国辐射卫生

2021, Vol. 30

Issue (2): 224-228 DOI: 10.13491/j.issn.1004-714X.2021.02.022

诊断与治疗/论著

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腰椎转移瘤不同射野角度调强放疗计划的剂量学研究

刘茹佳, 钟志鹏, 焦杨, 张伟鹏, 李韵秋, 陈颖

荆门市第二人民医院放疗科，湖北荆门 448000

Dosimetric study of intensity-modulated radiotherapy with different gantry angle for lumbar spinal metastases

LIU Rujia, ZHONG Zhipeng, JIAO Yang, ZHANG Weipeng, LI Yunqiu, CHEN Ying

Department of Radiotherapy, Jingmen NO.2 People’s Hospital, Jingmen 448000 China

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摘要目的比较腰椎转移瘤3种不同射野角度调强放疗（IMRT）计划中靶区及其周围正常组织受照剂量的差异。方法选择10例腰椎转移瘤患者，以3000 cGy /10F处方剂量分别对同一患者设计七野均分（plan-A）、五后野（plan-B）、七后野（plan-C）3种调强放疗计划，所有计划均使用相同的目标函数和剂量限制条件。采用SPSS 21.0统计学软件进行数据分析，评价3种调强放疗计划的靶区、危及器官、正常组织的剂量学参数以及治疗参数差异。结果 3种调强放疗计划均能满足临床要求，对于计划靶区的D_mean、D_2%、D_98%、CI、HI，plan-A与plan-C的差异无统计学意义（P > 0.05），且均优于plan-B（P < 0.05）。对于双侧肾脏的受照剂量，plan-B低于另外2种计划（P < 0.05）；对于脊髓的D_max，plan-B高于另外2种计划（P < 0.05）；对于正常组织的V₅、V₁₀，plan-B低于另外2种计划（P < 0.05），对于正常组织的V₁₅、V₂₀、V₂₅，plan-B均高于另外2种计划（P < 0.05）。在治疗参数方面，plan-B的机器跳数和治疗时间最优 (P < 0.05)。结论七野均分（plan-A）和七后野（plan-C）IMRT计划在靶区剂量分布及降低脊髓D_max方面较优；五后野（plan-B）IMRT计划在保护双侧肾脏及缩短治疗时间上更具优势。

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	刘茹佳
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	陈颖

关键词 ：腰椎, 骨转移瘤, 调强放疗, 剂量学

收稿日期: 2020-07-04

PACS:

R816.8

基金资助:荆门市引导性科研计划项目（2018YDKY039）

通讯作者: 陈颖,E-mail:jmeycy@163.com E-mail: jmeycy@163.com

作者简介: 刘茹佳(1991-),女,湖北咸宁人,主管技师,主要从事医学物理工作,E-mail:liurujia1234@126.com

引用本文:

刘茹佳, 钟志鹏, 焦杨, 张伟鹏, 李韵秋, 陈颖. 腰椎转移瘤不同射野角度调强放疗计划的剂量学研究[J]. 中国辐射卫生, 2021, 30(2): 224-228.
LIU Rujia, ZHONG Zhipeng, JIAO Yang, ZHANG Weipeng, LI Yunqiu, CHEN Ying. Dosimetric study of intensity-modulated radiotherapy with different gantry angle for lumbar spinal metastases. , 2021, 30(2): 224-228.

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