Effects of different dose ionizing radiation on the transcriptional level of DNA damage repair related genes in human peripheral blood lymphocytes
CHEN Huifeng1, TAN Siwen1,2, YAN Xuehua1, WANG Qia1, YANG Yuhua1, ZOU Jianming1
1. Guangdong Province Hospital for Occupational Disease Prevention and Treatmen, Guangdong Provincial Key Laboratory of Occupational Diseases Prevention and Treatment, Guangzhou 510300 China; 2. Guangdong Medical University
陈慧峰, 谭斯文, 闫雪华, 王恰, 杨宇华, 邹剑明. 不同剂量电离辐射对人外周血淋巴细胞DNA损伤修复相关基因转录水平的影响[J]. 中国辐射卫生, 2020, 29(1): 7-12.
CHEN Huifeng, TAN Siwen, YAN Xuehua, WANG Qia, YANG Yuhua, ZOU Jianming. Effects of different dose ionizing radiation on the transcriptional level of DNA damage repair related genes in human peripheral blood lymphocytes. , 2020, 29(1): 7-12.
[1] Wakeford R, Tawn E J. The meaning of low dose and low dose-rate[J]. J Radiol Prot, 2010, 30(1): 1-3 [2] 张琳, 刘东仁, 侯殿俊, 等. 不同剂量X射线照射对介入放射工作人员离体外周血淋巴细胞凋亡率的影响[J]. 中国辐射卫生,2019,28(4):368-370 [3] 赵玉倩, 苏垠平, 孙全富. 低剂量辐射照射与心血管疾病关系的流行病学研究进展[J]. 中国辐射卫生,2018,27(2):188-192 [4] 吕玉民. 染色体畸变在急、慢性辐射损伤评估中的意义专家解析[J]. 中国辐射卫生,2019,28(4):349-354, 360 [5] Tang F R, Loganovsky K. Low dose or low dose rate ionizing radiation-induced health effect in the human[J]. J Environ Radioact, 2018, 192: 32-47 [6] 陈慧峰, 郭强之, 刘明, 等. 广东高本底地区人群氧化损伤及抗氧化水平调查[J]. 中华放射医学与防护杂志,2015,35(2):83-87 [7] 董小梅. 低剂量电离辐射职业接触人群的遗传损伤和氧化-抗氧化效应的研究[D]. 重庆: 第三军医大学, 2015. [8] Mumby M. PP2A: unveiling a reluctant tumor suppressor[J]. Cell, 2007, 130(1): 21-24 [9] Lambrecht C, Haesen D, Sents W, et al. Structure, regulation, and pharmacological modulation of PP2A phosphatases[J]. Methods Mol Biol, 2013, 1053: 283-305 [10] Bennin D A, Don A S, Brake T, et al. Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest[J]. J Biol Chem, 2002, 277(30): 27449-27467 [11] 陈忠民, 刘波, 南新中, 等. 低剂量电离辐射损伤检测技术及其研究进展[J]. 中国辐射卫生,2017,26(2):254-256 [12] 徐维强, 唐庚, 刘纯岩, 等. 辐射对沉默ATRX的H460细胞增殖以及DNA损伤修复的影响[J]. 中国辐射卫生,2019,28(4):364-367 [13] Vaiserman A M. Hormesis and epigenetics: is there a link?[J]. Ageing Res Rev, 2011, 10(4): 413-421 [14] Feinendegen L E. The role of adaptive responses following exposure to ionizing radiation[J]. Hum Exp Toxicol, 1999, 18(7): 426-432 [15] 刘芳, 吴媚, 张遵真. hOGG1核酶介导的肺癌细胞对60Co-γ射线放射敏感性的研究[J]. 中华放射医学与防护杂志,2010,30(2):133-137 [16] 苏世标, 邹剑明, 耿继武, 等. 高本底辐射居民DNA损伤修复能力研究[J]. 中国职业医学,2010,37(1):15-17 [17] 苏世标, 靳雅丽, 郭强之, 等. 阳江高本底地区居民8-羟基脱氧鸟苷及其修复基因8-羟基鸟嘌呤DNA糖苷酶表达水平[J]. 中国职业医学,2012,39(6):467-470 [18] 李曼蓉. EGCG对慢性低剂量X线辐射诱导的细胞DNA甲基化影响的研究[D]. 扬州: 扬州大学, 2014. [19] Yan Y, Cao P T, Greer P M, et al. Protein phosphatase 2A has an essential role in the activation of Gamma-irradiation-induced G2/M checkpoint response[J]. Oncogene, 2010, 29(30): 4317-4329 [20] 陈慧峰, 罗洁, 林丽娜, 等. 蛋白磷酸酶2A-Aα亚基基因5'侧翼区多态性在广东汉族人群中的分布[J]. 癌变·畸变·突变,2011,23(2):93-97 [21] Remmerie M, Janssens V. PP2A: a promising biomarker and therapeutic target in endometrial cancer[J]. Front Oncol, 2019, 9: 462 [22] Avni D, Yang H, Martelli F, et al. Active localization of the retinoblastoma protein in chromatin and its response to S phase DNA damage[J]. Mol Cell, 2003, 12(3): 735-746 [23] 庄群瑛. miR-133b调控蛋白磷酸酶2A-B55δ亚基影响肝细胞癌化疗敏感性的机制研究[D]. 厦门: 厦门大学, 2016.
