The effects of radiation on proliferation and DNA damage repair in H460 cells silenced ATRX
XU Weiqiang1, TANG Geng1, LIU Chunyan2, LI Xin1, YANG Yanming3, GONG Shouliang1, YU Lei3, WANG Zhicheng1
1. NHC Key laboratory of Radiobiology(Jilin University), School of Public Health, Jilin University, Changchun 130021 China; 2. Department of Radiology, Second Hospital of Jilin University; 3. Department of Radiotherapy, Second Hospital of Jilin University
徐维强, 唐庚, 刘纯岩, 李鑫, 杨艳明, 龚守良, 于雷, 王志成. 辐射对沉默ATRX的H460细胞增殖以及DNA损伤修复的影响[J]. 中国辐射卫生, 2019, 28(4): 364-367.
XU Weiqiang, TANG Geng, LIU Chunyan, LI Xin, YANG Yanming, GONG Shouliang, YU Lei, WANG Zhicheng. The effects of radiation on proliferation and DNA damage repair in H460 cells silenced ATRX. , 2019, 28(4): 364-367.
[1] Ramamoorthy M, Smith S. Loss of ATRX suppresses resolution of telomere cohesion to control recombination in ALT cancer cells[J]. Cancer Cell, 2015, 28(3):357-369. [2] Scott H S. Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway[J]. PLoS Genet, 2012, 8(7):e1002772. [3] de Wilde R F, Heaphy C M, Maitra A, et al. Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors[J]. Mod Pathol, 2012, 25(7):1033-1039. [4] Kuefner MA, Brand M, Engert C, et al. Radiation Induced DNA Double-Strand Breaks in Radiology[J]. Rofo, 2015, 187(10):872-878. [5] 李世龙,刘波,陈文忠,等.C形臂X射线机扫描对小鼠的辐射损伤研究[J].中国辐射卫生, 2015, 24(1):56-58. [6] Alipoor A, Fardid R, Sharifzadeh S. Evaluating Gamma-H2AX Expression as a Biomarker of DNA Damage after X-ray in Angiography Patients[J]. J Biomed Phys Eng, 2018, 8(4):393-402. [7] 何楚琦,王月,龙鼎新.电磁辐射对中枢神经系统的影响及机制[J].中国辐射卫生, 2017, 26(3):381-384. [8] 蒋超,张鹏程,王晓炜,等.二甲双胍对肺癌细胞A549放疗增敏作用及机制研究[J].中国辐射卫生, 2017, 26(6):718-722. [9] Ceccaldi R, Rondinelli B, D'Andrea A D. Repair pathway choices and consequences at the double-strand break[J]. Trends in Cell Biology, 2016, 26(1):52-64. [10] Voon H P J, Hughes J R, Rode C, et al. ATRX plays a key role in maintaining silencing at interstitial heterochromatic loci and imprinted genes[J]. Cell Reports, 2015, 11(3):405-418. [11] Noh K M, Maze I, Zhao D, et al. ATRX tolerates activity-dependent histone H3 methyl/phos switching to maintain repetitive element silencing in neurons[J]. Proc Natl Acad Sci USA, 2015, 112(22):6820-6827. [12] Wood R D, Doublié S. DNA polymerase θ (POLQ), double-strand break repair, and cancer[J]. DNA Repair, 2016, 44:22-32. [13] Chua M L K, Horn S, Somaiah N, et al. DNA double-strand break repair and induction of apoptosis in ex vivo irradiated blood lymphocytes in relation to late normal tissue reactions following breast radiotherapy[J]. Radiat Environ Biophys, 2014, 53(2):355-364. [14] Haines J W, Coster M, Bouffler S D. Impairment of the non-homologous end joining and homologous recombination pathways of DNA double strand break repair:Impact on spontaneous and radiation-induced mammary and intestinal tumour risk in Apcmin/+ mice[J]. DNA Repair, 2015, 35:19-26.
