李婷, 王林平, 梁婧. 肠道微生态对放射治疗的影响与相关机制[J]. 中国辐射卫生, 2019, 28(2): 214-217.
LI Ting, WANG Linping, LIANG Jing. Effect and mechanism of gut microbiota on radiotherapy. , 2019, 28(2): 214-217.
[1] O'Hara A M, Shanahan F. The gut flora as a forgotten organ[J]. EMBO Rep, 2006, 7(7):688-693. [2] Costello E K, Stagaman K, Dethlefsen L, et al. The application of ecological theory toward an understanding of the human microbiome[J]. Science, 2012, 336(6086):1255-1262. [3] Dzutsev A, Goldszmid R S, Viaud S, et al. The role of the microbiota in inflammation, carcinogenesis, and cancer therapy[J]. Eur J Immunol, 2015, 45(1):17-31. [4] Vaishnava S, Behrendt C L, Ismail A S, et al. Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface[J]. Proc Natl Acad Sci USA, 2008, 105(52):20858-20863. [5] Peterson L W, Artis D. Intestinal epithelial cells:regulators of barrier function and immune homeostasis[J]. Nat Rev Immunol, 2014, 14(3):141-153. [6] Belkaid Y, Naik S. Compartmentalized and systemic control of tissue immunity by commensals[J]. Nat Immunol, 2013, 14(7):646-653. [7] Sender R, Fuchs S, Milo R. Revised Estimates for the Number of Human and Bacteria Cells in the Body[J]. PLoS Biol, 2016, 14(8):e1002533. [8] Chow J, Tang H, Mazmanian S K. Pathobionts of the gastrointestinal microbiota and inflammatory disease[J]. Curr Opin Immunol, 2011, 23(4):473-480. [9] Wells J M, Rossi O, Meijerink M, et al. Epithelial crosstalk at the microbiota-mucosal interface[J]. Proc Natl Acad Sci USA, 2011, 108(Suppl 1):4607-4614. [10] Eckburg P B, Bik E M, Bernstein C N, et al. Diversity of the human intestinal microbial flora[J]. Science, 2005, 308(5728):1635-1638. [11] Qin J, Li R, Raes J, et al. A human gut microbial gene catalogue established by metagenomic sequencing[J]. Nature, 2010, 464(7285):59-65. [12] Yu J, Feng Q, Wong S H, et al. Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer[J]. Gut, 2017, 66(1):70-78. [13] Goodrich J K, Waters J L, Poole A C, et al. Human genetics shape the gut microbiome[J]. Cell, 2014, 159(4):789-799. [14] David L A, Maurice C F, Carmody R N, et al. Diet rapidly and reproducibly alters the human gut microbiome[J]. Nature, 2014, 505(7484):559-563. [15] Mavragani I V, Laskaratou D A, Frey B, et al. Key mechanisms involved in ionizing radiation-induced systemic effects. A current review[J]. Toxicol Res (Camb), 2016, 5(1):12-33. [16] Vacchelli E, Vitale I, Tartour E, et al. Trial Watch:Anticancer radioimmunotherapy[J]. Oncoimmunology, 2013, 2(9):e25595. [17] Pateras I S, Havaki S, Nikitopoulou X, et al. The DNA damage response and immune signaling alliance:Is it good or bad? Nature decides when and where[J]. Pharmacol Ther, 2015, 154:36-56. [18] Nikitaki Z, Mavragani I V, Laskaratou D A, et al. Systemic mechanisms and effects of ionizing radiation:A new ‘old’ paradigm of how the bystanders and distant can become the players[J]. Semin Cancer Biol, 2016, 37-38:77-95. [19] Ermolaeva M A, Segref A, Dakhovnik A, et al. DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance[J]. Nature, 2013, 501(7467):416-420. [20] Al-Mayah A, Bright S, Chapman K, et al. The non-targeted effects of radiation are perpetuated by exosomes[J]. Mutat Res, 2015, 772:38-45. [21] Demaria S, Formenti S C. Radiation as an immunological adjuvant:current evidence on dose and fractionation[J]. Frontiers in Oncology, 2012, 2. [22] Demaria S, Ng B, Devitt M L, et al. Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated[J]. International Journal of Radiation Oncology Biology Physics, 2004, 58(3):862-870. [23] Viaud S, Saccheri F, Mignot G, et al. The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide[J]. Science, 2013, 342(6161):971-976. [24] Iida N, Dzutsev A, Stewart CA, et al. Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment[J]. Science, 2013, 342(6161):967-970. [25] Zitvogel L, Ayyoub M, Routy B, et al. Microbiome and Anticancer Immunosurveillance[J]. Cell, 2016, 165(2):276-287. [26] Deng L, Liang H, Burnette B, et al. Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice[J]. J Clin Invest, 2014, 124(2):687-695. [27] Barker HE, Paget J T, Khan A A, et al. The tumour microenvironment after radiotherapy:mechanisms of resistance and recurrence[J]. Nat Rev Cancer, 2015, 15(7):409-425. [28] Belkaid Y, Hand T W. Role of the microbiota in immunity and inflammation[J]. Cell, 2014, 157(1):121-141. [29] Wang A, Ling Z, Yang Z, et al. Gut microbial dysbiosis may predict diarrhea and fatigue in patients undergoing pelvic cancer radiotherapy:a pilot study[J]. PLoS ONE, 2015, 10(5):e0126312. [30] Chu H, Mazmanian S K. Innate immune recognition of the microbiota promotes host-microbial symbiosis[J]. Nature Immunology, 2013, 14(7):668-675. [31] Jones R M, Desai C, Darby T M, et al. Lactobacilli Modulate Epithelial Cytoprotection through the Nrf2 Pathway[J]. Cell Rep, 2015, 12(8):1217-1225. [32] Takemura N, Kawasaki T, Kunisawa J, et al. Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome[J]. Nature Communications, 2014, 5(5):3492. [33] Hu B, Jin C, Li H B, et al. The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury[J]. Science, 2016, 354(6313):765-768. [34] Ciorba M A, Riehl T E, Rao M S, et al. Lactobacillus probiotic protects intestinal epithelium from radiation injury in a TLR-2/cyclo-oxygenase-2-dependent manner[J]. Gut, 2012, 61(6):829-838. [35] Touchefeu Y, Montassier E, Nieman K, et al. Systematic review:the role of the gut microbiota in chemotherapy- or radiation-induced gastrointestinal mucositis-current evidence and potential clinical applications[J]. Aliment Pharmacol Ther, 2014, 40(5):409-421. [36] Sharma A, Rath G K, Chaudhary S P, et al. Lactobacillus brevis CD2 lozenges reduce radiation- and chemotherapy-induced mucositis in patients with head and neck cancer:a randomized double-blind placebo-controlled study[J]. Eur J Cancer, 2012, 48(6):875-881. [37] Crawford P A, Gordon J I. Microbial regulation of intestinal radiosensitivity[J]. Proc Natl Acad Sci USA, 2005, 102(37):13254-13259. [38] Santulli G. Angiopoietin-like proteins:a comprehensive look[J]. Front Endocrinol (Lausanne), 2014, 5:4. [39] Ishihara H, Tanaka I, Yakumaru H, et al. Circadian transitions in radiation dose-dependent augmentation of mRNA levels for DNA damage-induced genes elicited by accurate real-time RT-PCR quantification[J]. J Radiat Res, 2010, 51(3):265-275. [40] Liang X, Bushman F D, FitzGerald G A. Rhythmicity of the intestinal microbiota is regulated by gender and the host circadian clock[J]. Proc Natl Acad Sci USA, 2015, 112(33):10479-10484. [41] Thaiss C A, Zeevi D, Levy M, et al. Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis[J]. Cell, 2014, 159(3):514-529. [42] Maier I, Berry D M, Schiestl R H. Intestinal microbiota reduces genotoxic endpoints induced by high-energy protons[J]. Radiat Res, 2014, 181(1):45-53.