Sensitizing effect and Mechanism of metformin on radiotherapy of lung carcinoma A549 cells
JIANG Chao1, ZHANG Pengcheng2, Wang Xiaowei1, GAO Yong1
1. Department of Oncology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an 223300 China; 2. Department of Radiation Oncology, Tianjin Medical University General Hospital
[1] Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010[J].CA Cancer J Clin, 2010, 60(5):277-300. [2] Timmerman R, Paulus R, Galvin J, et al. Stereotactic body radiation therapy for inoperable early stage lung cancer[J].JAMA, 2010,303(11):1070-1076. [3] Wan G, Yu X, Chen P, et al. Metformin therapy associated with survival benefit in lung cancer patients with diabetes[J].Oncotarget, 2016, 7(23):35437-35445. [4] Suwei D, Liang Z, Zhimin L, et al. NLK functions to maintain proliferation and stemness of NSCLC and is a target of metformin[J].J Hematol Oncol, 2015, 8:120. [5] Coyle C, Cafferty FH, Vale C, et al. Metformin as an adjuvant treatment for cancer:a systematic review and meta-analysis[J].Ann Oncol, 2016, 27(12):2184-2195. [6] Lin ZZ, Chou CH, Cheng AL, et al. Radiosensitization by combining an aurora kinase inhibitor with radiotherapy in hepatocellular carcinoma through cell cycle interruption[J].Int J Cancer, 2014,135(2):492-501. [7] Grosse J, Warnke e, Wehland M, et al. Mechanisms of apoptosis in irradiated and sunitinib-treated follicular thyroid cancer cells[J].Apoptosis,2014,19(3):480-490. [8] Li H, Chen X, Yu Y, et al. Metformin inhibits the growth of nasopharyngeal carcinoma cells and sensitizes the cells to radiation via inhibition of the DNA damage repair pathway[J].Oncol Rep,2014,32(6):2596-2604. [9] H. Dixon, CJ. Norbury. Therapeutic exploitation of checkpoint defects in cancer cells lacking p53 function[J].Cell Cycle, 2002, 1(6):362-368. [10] Zhang X, Huang Q, Wang X, et al. Bufalin enhances radiosensitivity of glioblastoma by suppressing mitochondrial function and DNA damage repair[J].Biomed Pharmacother,2017,94:627-635. [11] Lee Y, Li HK, Masaoka A, et al. The purine scaffold Hsp90 inhibitor PU-H71 sensitizes cancer cells to heavy ion radiation by inhibiting DNA repair by homologous recombination and non-homologous end joining[J].Radiother Oncol, 2016, 121(1):162-168. [12] Someya M, Hasegawa T, Hori M, et al. Local tumor control and DNA-PK activity of peripheral blood lymphocytes in prostate cancer patients receiving radiotherapy[J].J Radiat Res,2017,58(2):225-231.
