间充质干细胞来源胞外囊泡救治辐射损伤的研究进展

doi:10.13491/j.issn.1004-714x.2018.04.022

中国辐射卫生

2018, Vol. 27

Issue (4): 369-371 DOI: 10.13491/j.issn.1004-714x.2018.04.022

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间充质干细胞来源胞外囊泡救治辐射损伤的研究进展

王利^1,2, 马得勋³, 许长春¹, 高蕊¹, 高春记², 刘书锋³

1. 解放军第401医院崂山分院血液肿瘤科, 山东青岛 266101;
2. 解放军总医院血液科;
3. 解放军第401医院崂山分院核防护科

Role of mesenchymal stem cell derived extracellular vesicles in radiation injuries

WANG Li^1,2, MA Dexun³, XU Changchun¹, GAO Rui¹, GAO Chunji², LIU Shufeng³

1. Department of Hematology and Oncology, Laoshan Branch of No. 401 Hospital of Chinese PLA, Qingdao 266101 China;
2. Department of Hematology, Chinese PLA General Hospital;
3. Department of radiation protection, Laoshan Branch of No. 401 Hospital of Chinese PLA

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摘要间充质干细胞来源胞外囊泡（MSC-EV）在保留间充质干细胞（MSC）生物学功能的同时，能够避免MSC内在缺陷；MSC-EV脂质双分子层结构能够避免其脂质、蛋白、DNA、RNA等内容物被酶类物质降解；此外，MSC-EV适合通过永生化MSC技术进行大规模制备。因此，与MSC相比，MSC-EV是一种新型高效、安全、便捷、可行的非细胞治疗方法，且在组织修复及免疫调节方面呈现出同等功效。本文仅就MSC-EV在辐射损伤救治方面的研究进展作一综述。

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	王利
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	刘书锋

关键词 ：间充质干细胞, 胞外囊泡, 辐射损伤

收稿日期: 2018-02-12

PACS:

R818

基金资助:国家自然科学基金（81270642，81070451）；北京市自然科学基金（7162175）；海南省社会发展基金（SF201306）；解放军总医院百项优势项目（YS201451）；军队后勤计划项目（cjn15j001）

通讯作者: 刘书锋,E-mail:wf8439231@163.com E-mail: wf8439231@163.com

作者简介: 王利(1984-),男,山西翼城人,博士,主治医师,从事血液病及辐射损伤的诊治工作及间充质干细胞的相关应用。E-mail:wangliplagh@163.com

引用本文:

王利, 马得勋, 许长春, 高蕊, 高春记, 刘书锋. 间充质干细胞来源胞外囊泡救治辐射损伤的研究进展[J]. 中国辐射卫生, 2018, 27(4): 369-371.
WANG Li, MA Dexun, XU Changchun, GAO Rui, GAO Chunji, LIU Shufeng. Role of mesenchymal stem cell derived extracellular vesicles in radiation injuries. , 2018, 27(4): 369-371.

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http://www.zgfsws.com/CN/10.13491/j.issn.1004-714x.2018.04.022 或 http://www.zgfsws.com/CN/Y2018/V27/I4/369

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