有无均整器模式下海马保护全脑放疗剂量学比较

doi:10.13491/j.issn.1004-714X.2022.06.018

中国辐射卫生

2022, Vol. 31

Issue (6): 740-745 DOI: 10.13491/j.issn.1004-714X.2022.06.018

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有无均整器模式下海马保护全脑放疗剂量学比较

邵伟¹, 刘静¹, 孙毅², 王刚¹, 郭兴照¹, 孙多平¹, 傅强¹

1. 青岛市市立医院，山东青岛 66000;
2. 青岛即墨区鳌山卫卫生院，山东青岛 266237

Dosimetric comparison of hippocampal avoidance wholebrain radiotherapy with flattening filter and flattening filter-free modes

SHAO Wei¹, LIU Jing¹, SUN Yi², WANG Gang¹, GUO Xingzhao¹, SUN Duoping¹, FU Qiang¹

1. Qingdao Municipal Hospital, Qingdao 266000 China;
2. Qingdao Jimo Aoshanwei Health Center, Qingdao 266237 China

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摘要目的探讨采用有均整器（FF）和无均整器(FFF)模式下容积旋转调强在海马保护性全脑放疗中的剂量学差异。方法选取15例海马保护全脑放疗患者，对每例患者设计FF-VAMT和FFF-VMAT 2种放疗计划，达到临床剂量要求前提下，进行剂量学、机器总跳数、出束总时间比较。结果 2种计划相比，在靶区覆盖率、适形度和剂量梯度上的差异无统计学意义（P > 0.05）。在海马体组织D_max、D_100%、D_mean 3项剂量参数上，FFF-VAMT计划可分别控制在（15.13 ± 0.38） Gy、（7.12 ± 0.34） Gy 和（9.76 ± 0.43） Gy，明显小于FF-VAMT计划的（16.46 ± 0.56） Gy、（7.72 ± 0.28） Gy、（10.54 ± 0.48） Gy，差异均有统计学意义（P < 0.05）；左右晶体的D_max与眼球D_mean分别为（7.26 ± 0.43） Gy、（6.29 ± 1.13） Gy、（11.01 ± 0.94） Gy、（9.78 ± 1.13） Gy明显小于FF-VAMT计划（8.09 ± 0.66） Gy、（7.80 ± 0.74） Gy、（11.38 ± 1.09） Gy、（11.05 ± 0.90） Gy（P < 0.05）。其它危及器官如视神经视交叉等剂量均控制在临床安全剂量范围内，且两计划之间差异无统计学意义（P > 0.05）；FFF-VAMT计划MU值大于FF-VMAT计划，出束时间小于FF-VMAT计划，差异有统计学意义（P < 0.05）。结论 FF-VAMT和 FFF-VAMT 2种放疗方式均能满足临床需求，FFF-VAMT放疗方式对海马体和晶体的保护上更具优势，且FFF模式出束时间短，治疗效率高。

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	邵伟
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	孙多平
	傅强

关键词 ：全脑放疗, 海马体, 无均整器模式, 容积旋转调强放疗, 剂量学

收稿日期: 2022-02-21

PACS:

X591

通讯作者: 傅强，E-mail：sunnydaily@126.com E-mail: sunnydaily@126.com

作者简介: 邵伟（1994—），男，青岛人，初级技师，从事放疗物理工作（放疗计划设计与放疗质控）。E-mail：895093175@qq.com

引用本文:

邵伟, 刘静, 孙毅, 王刚, 郭兴照, 孙多平, 傅强. 有无均整器模式下海马保护全脑放疗剂量学比较[J]. 中国辐射卫生, 2022, 31(6): 740-745.
SHAO Wei, LIU Jing, SUN Yi, WANG Gang, GUO Xingzhao, SUN Duoping, FU Qiang. Dosimetric comparison of hippocampal avoidance wholebrain radiotherapy with flattening filter and flattening filter-free modes. Chinese Journal of Radiological Health, 2022, 31(6): 740-745.

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