Effects of low-dose radiation on oxidative stress and damage repair in HBE cells
ZHOU Linqian1,2, HUANG Weixu2, CAI Lina2,3, KE Weiyi2,3, ZHANG Lingyu1,2, CAI Yashi2,4, ZHANG Sufen2, YANG Ping1, ZOU Jianming2, CHEN Huifeng1,2
1. School of Public Health, Guangzhou Medical University, Guangzhou 511436 China; 2. Guangdong Key Laboratory of Occupational Disease Prevention and Control, Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou 510300 China; 3. School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510006 China; 4. School of Public Health, Southern Medical University, Guangzhou 510515 China
[1] United Nations Scientific Committee on the Effects of Atomic Radiation. Report of the United Nations Scientific Committee on the Effects of Atomic Radiation 2010[Z]. New York: United Nations, 2011. [2] 陈慧峰, 郭强之, 刘明, 等. 广东高本底地区人群氧化损伤及抗氧化水平调查[J]. 中华放射医学与防护杂志,2015,35(2):83-87. DOI: 10.3760/cma.j.issn.0254-5098.2015.02.002 Chen HF, Guo QZ, Liu M, et al. The effects of low dose radiation on the levels of oxidative damage and antioxidant in population of high background radiation area of Guangdong[J]. Chin J Radiol Med Prot, 2015, 35(2): 83-87. DOI: 10.3760/cma.j.issn.0254-5098.2015.02.002 [3] Bankoglu EE, Gerber J, Kodandaraman G, et al. Influence of bariatric surgery induced weight loss on oxidative DNA damage[J]. Mutat Res Genet Toxicol Environ Mutagen, 2020, 853: 503194. DOI: 10.1016/j.mrgentox.2020.503194 [4] Ghahe SS, Kosicki K, Wojewódzka M, et al. Increased DNA repair capacity augments resistance of glioblastoma cells to photodynamic therapy[J]. DNA Repair (Amst), 2021, 104: 103136. DOI: 10.1016/j.dnarep.2021.103136 [5] 赵文迪, 田健, 周建炜. 低剂量/低剂量率电离辐射减轻放射性损伤的研究进展[J]. 河南大学学报(医学版),2021,40(5):372-376. DOI: 10.15991/j.cnki.41-1361/r.2021.05.012 Zhao WD, Tian J, Zhou JW. Research progress of low-dose/low-dose-rate ionizing radiation in reducing radiation damage[J]. J Henan Univ (Med Sci), 2021, 40(5): 372-376. DOI: 10.15991/j.cnki.41-1361/r.2021.05.012 [6] Harris IS, DeNicola GM. The complex interplay between antioxidants and ROS in cancer[J]. Trends Cell Biol, 2020, 30(6): 440-451. DOI: 10.1016/j.tcb.2020.03.002 [7] Lei G, Zhang YL, Koppula P, et al. The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression[J]. Cell Res, 2020, 30(2): 146-162. DOI: 10.1038/s41422-019-0263-3 [8] 常馨月, 米晓, 董明然, 等. 巴西海木提取物抗生殖系统氧化损伤活性研究[J]. 中南药学,2022,20(4):751-758. DOI: 10.7539/j.issn.1672-2981.2022.04.005 Chang XY, Mi X, Dong MR, et al. Antioxidant activity of Trichilia catigua A. Juss. against damage in the reproductive system[J]. Central South Pharm, 2022, 20(4): 751-758. DOI: 10.7539/j.issn.1672-2981.2022.04.005 [9] 杨柳春, 王克义. DNA氧化损伤标志物8-羟基脱氧鸟苷与相关肿瘤关系的研究进展[J]. 浙江医学,2021,43(23):2608-2612. DOI: 10.12056/j.issn.1006-2785.2021.43.23.2021-3119 Yang LC, Wang KY. Advances in the relationship between 8-hydroxydeoxyguanosine, a marker of oxidative DNA damage, and related tumours[J]. Zhejiang Med J, 2021, 43(23): 2608-2612. DOI: 10.12056/j.issn.1006-2785.2021.43.23.2021-3119 [10] Fijen C, Rothenberg E. The evolving complexity of DNA damage foci: RNA, condensates and chromatin in DNA double-strand break repair[J]. DNA Repair (Amst), 2021, 105: 103170. DOI: 10.1016/j.dnarep.2021.103170 [11] 余小玲, 荣利, 方芳, 等. 低剂量X线辐射对A549细胞凋亡的适应性反应[J]. 中国辐射卫生,2022,31(2):139-143,148. DOI: 10.13491/j.issn.1004-714X.2022.02.001 Yu XL, Rong L, Fang F, et al. Adaptive response of A549 cell apoptosis induced by low-dose X-ray irradiation[J]. Chin J Radiol Health, 2022, 31(2): 139-143,148. DOI: 10.13491/j.issn.1004-714X.2022.02.001 [12] Boutelle AM, Attardi LD. p53 and tumor suppression: it takes a network[J]. Trends Cell Biol, 2021, 31(4): 298-310. DOI: 10.1016/j.tcb.2020.12.011 [13] Mumby M. PP2A: unveiling a reluctant tumor suppressor[J]. Cell, 2007, 130(1): 21-24. DOI: 10.1016/j.cell.2007.06.034 [14] Lambrecht C, Haesen D, Sents W, et al. Structure, regulation, and pharmacological modulation of PP2A phosphatases[M]//Millán JL. Phosphatase Modulators. Totowa: Humana Press, 2013: 283-305. DOI: 10.1007/978-1-62703-562-0_17. [15] 陈慧峰, 谭斯文, 闫雪华, 等. 不同剂量电离辐射对人外周血淋巴细胞DNA损伤修复相关基因转录水平的影响[J]. 中国辐射卫生,2020,29(1):7-12. DOI: 10.13491/j.issn.1004-714X.2020.01.002 Chen HF, Tan SW, Yan XH, et al. Effects of different dose ionizing radiation on the transcriptional level of DNA damage repair related genes in human peripheral blood lymphocytes[J]. Chin J Radiol Health, 2020, 29(1): 7-12. DOI: 10.13491/j.issn.1004-714X.2020.01.002 [16] Kim SY, Hyun SY, Jang YJ. Dephosphorylation of Plk1 occurs through PP2A-B55/ENSA/Greatwall pathway during mitotic DNA damage recovery[J]. Cell Cycle, 2019, 18(10): 1154-1167. DOI: 10.1080/15384101.2019.1617003 [17] 王茂枝, 刘森林. 辐射的来源漫谈[J]. 中国辐射卫生,2021,30(2):238-243. DOI: 10.13491/j.issn.1004-714X.2021.02.025 Wang MZ, Liu SL. The sources of radiation[J]. Chin J Radiol Health, 2021, 30(2): 238-243. DOI: 10.13491/j.issn.1004-714X.2021.02.025 [18] 唐颖. 阳江高本底辐射地区居民IL-2、IL-2R基因表达水平和IL-2R基因多态性研究[D]. 广州: 广东药科大学, 2020. DOI: 10.27690/d.cnki.ggdyk.2020.000258. Tang Y. Study on IL-2, IL-2R gene expression level and IL-2R gene polymorphism in Yangjiang high background radiation area[D]. Guangzhou: Guangdong Pharmaceutical University, 2020. DOI: 10.27690/d.cnki.ggdyk.2020.000258. [19] 康爽, 谭业辉, 郎悦. 低剂量辐射对人骨髓间充质干细胞的兴奋效应[J]. 中国老年学杂志,2015,35(9):2586-2588. DOI: 10.3969/j.issn.1005-9202.2015.09.133 Kang S, Tan YH, Lang Y. Excitatory effects of low-dose radiation on human bone marrow mesenchymal stem cells[J]. Chin J Gerontol, 2015, 35(9): 2586-2588. DOI: 10.3969/j.issn.1005-9202.2015.09.133 [20] Konkova M, Abramova M, Kalianov A, et al. Mesenchymal stem cells early response to low-dose ionizing radiation[J]. Front Cell Dev Biol, 2020, 8: 584497. DOI: 10.3389/fcell.2020.584497 [21] 杨国姿. ATM相关信号通路在低剂量辐射诱导肺正常及肿瘤细胞生物学效应差异中的作用及机制研究[D]. 长春: 吉林大学, 2016. Yang GZ. Distinct biological effects of low-dose radiation on lung normal and cancerous cells are mediated by ATM signaling[D]. Changchun: Jilin University, 2016. [22] 王琪, 赵珂, 高雅萌, 等. 电离辐射对小鼠造血干/祖细胞线粒体功能的影响[J]. 中华放射医学与防护杂志,2022,42(5):321-327. DOI: 10.3760/cma.j.cn112271-20220222-00064 Wang Q, Zhao K, Gao YM, et al. Effects of ionizing radiation on mitochondrial function of mouse hematopoietic stem and progenitor cells[J]. Chin J Radiol Med Prot, 2022, 42(5): 321-327. DOI: 10.3760/cma.j.cn112271-20220222-00064 [23] Tabatabaie F, Franich R, Feltis B, et al. Oxidative damage to mitochondria enhanced by ionising radiation and gold nanoparticles in cancer cells[J]. Int J Mol Sci, 2022, 23(13): 6887. DOI: 10.3390/ijms23136887 [24] 胡昌坤, 张雪梅, 马增春, 等. 低剂量辐射对小鼠肠道损伤的影响[J]. 辐射防护,2021,41(4):315-320 Hu CK, Zhang XM, Ma ZC, et al. Effects of low dose radiation on intestinal injury in mice[J]. Radiat Prot, 2021, 41(4): 315-320 [25] Winterbourn CC, Hampton MB. Thiol chemistry and specificity in redox signaling[J]. Free Radic Biol Med, 2008, 45(5): 549-561. DOI: 10.1016/j.freeradbiomed.2008.05.004 [26] 于卫国, 张杰, 张蕾, 等. 丹参对电离辐射致SD大鼠损伤的防护研究[J]. 江西医药,2019,54(10):1193-1195. DOI: 10.3969/j.issn.1006-2238.2019.10.014 Yu WG, Zhang J, Zhang L, et al. Protective effects of Danshen on SD rats induced by ionizing radiation[J]. Jiangxi Med J, 2019, 54(10): 1193-1195. DOI: 10.3969/j.issn.1006-2238.2019.10.014 [27] Jelic MD, Mandic AD, Maricic SM, et al. Oxidative stress and its role in cancer[J]. J Cancer Res Ther, 2021, 17(1): 22-28. DOI: 10.4103/jcrt.JCRT_862_16 [28] 刘明, 苏世标, 郭强之, 等. 高本底地区辐射对8-OHdG和hMTH1的影响研究[J]. 中国热带医学,2016,16(7):670-672. DOI: 10.13604/j.cnki.46-1064/r.2016.07.11 Liu M, Su SB, Guo QZ, et al. Impact of radiation on 8-OHd G and h MTH1 in high background radiation area[J]. China Trop Med, 2016, 16(7): 670-672. DOI: 10.13604/j.cnki.46-1064/r.2016.07.11 [29] Dung TD, Day CH, Binh TV, et al. PP2A mediates diosmin p53 activation to block HA22T cell proliferation and tumor growth in xenografted nude mice through PI3K-Akt-MDM2 signaling suppression[J]. Food Chem Toxicol, 2012, 50(5): 1802-1810. DOI: 10.1016/j.fct.2012.01.021