HFRT和CFRT模式对乳腺癌患者外周血淋巴细胞的影响

doi:10.13491/j.issn.1004-714X.2022.03.004

中国辐射卫生

2022, Vol. 31

Issue (3): 279-283,295 DOI: 10.13491/j.issn.1004-714X.2022.03.004

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HFRT和CFRT模式对乳腺癌患者外周血淋巴细胞的影响

刘逸晗^1,2, 殷海涛², 周云², 周冲², 任洪荣²

1. 徐州医科大学研究生院, 江苏徐州 221000;
2. 徐州医科大学徐州临床学院放疗科, 江苏徐州 221000

Effect of HFRT and CFRT on peripheral blood lymphocytes in patients with breast cancer

LIU Yihan^1,2, YIN Haitao², ZHOU Yun², ZHOU Chong², REN Hongrong²

1. Graduate School of Xuzhou Medical University, Xuzhou 221000 China;
2. Department of Radiotherapy, Xuzhou Clinical College of Xuzhou Medical University, Xuzhou 221000 China

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摘要目的探讨不同放疗分割模式即大分割放疗（hypofractionated radiotherapy, HFRT)和常规分割放疗（conventional fractionation radiotherapy, CFRT)对乳腺癌患者外周血淋巴细胞的影响。方法回顾性分析2019年11月至2021年8月在徐州市中心医院接受保乳术后放射治疗的40例早期乳腺癌患者。随机分为观察组（HFRT，n = 20）与对照组（CFRT，n = 20），比较2组患者放疗前及放疗中的外周血淋巴细胞计数(peripheral lymphocyte count，PLC)变化。结果大分割组和常规分割组患者的基线PLC无统计学差异（1.53 ± 0.54 vs 1.64 ± 0.56；P > 0.05）。2组的PLC在放疗过程中稳定下降，大分割组淋巴细胞减少发生率低于常规分割组（32.5% vs 50.0%)，但差异无统计学意义（P > 0.05）；大分割组的最低点PLC高于常规分割组（0.91 ± 0.28 vs 0.55 ± 0.22；P < 0.001）。大分割组治疗期间的最低PLC与基线阶段的比值明显高于常规分割组（0.64 ± 0.24 vs 0.38 ± 0.21，P < 0.05）。结论与常规分割放疗方案相比，乳腺癌患者接受大分割放疗发生放射诱导淋巴细胞减少的风险更低。

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	刘逸晗
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关键词 ：乳腺癌, 放射治疗, 外周淋巴细胞, 大分割放疗

收稿日期: 2021-10-17

PACS:

Q691

通讯作者: 殷海涛，E-mail：yinhaitao@njmu.edu.cn E-mail: yinhaitao@njmu.edu.cn

作者简介: 刘逸晗（1996—），女，安徽宿州人，硕士在读，专业：肿瘤学（放射治疗方向）。E-mail：2300306884@qq.com

引用本文:

刘逸晗, 殷海涛, 周云, 周冲, 任洪荣. HFRT和CFRT模式对乳腺癌患者外周血淋巴细胞的影响[J]. 中国辐射卫生, 2022, 31(3): 279-283,295.
LIU Yihan, YIN Haitao, ZHOU Yun, ZHOU Chong, REN Hongrong. Effect of HFRT and CFRT on peripheral blood lymphocytes in patients with breast cancer. Chinese Journal of Radiological Health, 2022, 31(3): 279-283,295.

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http://www.zgfsws.com/CN/10.13491/j.issn.1004-714X.2022.03.004 或 http://www.zgfsws.com/CN/Y2022/V31/I3/279

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